Identifying individual risk rare variants using protein structure-guided local tests.
PLOS Computational Biology, provisionally accepted. [Sofrware]
Adaptive false negative control under dependence with genomic applications.
Journal of the American Statistical Association, in press. NIHMSID:NIHMS988815
Genetic loci determining total immunoglobulin E levels from birth through adulthood.
Re-examining dis/similarity-based tests for rare-variant association with case-control samples.
Genetics, 209:105-113. PMCID: PMC5937191 [Paper]
A powerful test for SNP effects on multivariate binary outcomes using kernel machine regression.
On the substructure controls in rare variant analysis --- principal components or variance components?.
Genetic Epidemiology, 42:276-287. PMCID: PMC5851819 [Paper]
Inference on phenotype-specific effects of genes using multivariate kernel machine regression.
Genetic Epidemiology, 42:64-79. PMCID: PMC5768462. [Paper]
Cadmium Exposure Increases the Risk of Juvenile Obesity: A Human and Zebrafish Comparative Study.
International Journal of Obesity, 42:1285-1295 [Paper]
Rejoinder to "A note on testing and estimation in marker-set association study using semiparametric quantile regression kernel machine".
Biometrics, 74:767-768.. PMCID: PMC5932282 [Paper]
Bayesian Variable Screenings for Binary Response Regressions in High-Dimensional and Sparse Settings.
Journal of Statistical Computation and Simulation, 87, 2708-2723. PMCID: PMC5653235 [Paper]
Maternal blood concentrations of cadmium, lead and arsenic, nutrients, and offspring birth weight.
BMC Public Health, 17:354. PMCID: PMC5402649 [Paper]
Rare variants association analysis in large-scale sequencing studies at the single locus level.
PLoS Comoputational Biology, 12:e1004993. PMCID: PMC4927097 [Paper]
Testing and Estimation in Marker-Set Association Study Using Semiparametric Kernel Quantile Regression.
Biometrics, 72:364-71. NIHMSID: NIHMS735278 [Paper]
Detection of gene-gene interactions by multistage sparse and low-rank regression.
Biometrics, 72:85-94. NIHMSID: NIHMS697633 [paper]
Across-platform imputation of DNA methylation levels incorporating non-local information using penalized functional regression.
Genetic Epidemiology, 40:333-40 [paper]
A new method for detecting associations with rare copy-number variants.
A fast multiple-kernel method with applications to detect gene-environment interaction.
Proper use of allele-specific expression improves statistical power for cis-eQTL mapping with RNA-Seq data.
Journal of the American Statistical Association, 110, 962-974. PMCID: PMC4642818 [paper]
Assessing Gene-Environment Interactions for Common and Rare Variants with Binary Traits Using Gene-Trait Similarity Regression.
Module-based association analysis for omics data with network structure.
Plos One, 10(3):e0122309 PMCID: PMC4378989 [Paper]
A penalized likelihood approach for pharmacogenetic studies via understanding haplotype effect structures for gene and gene-drug interaction.
Biometrics, 71:529-37 PMCID: PMC4480191 [Paper]
Complete effect-profile assessment in association studies with multiple genetic and environmental factors.
Genetic Epidemiology, 39:122-33. PMCID: PMC4314365 [Paper]
Gene-level pharmacogenetic analysis on survival outcomes by gene-trait similarity regression.
Annals of Applied Statistics, 8:1232-1255. PMCID: PMC4091797 [Paper]
Integrative Gene Set Analysis of Multi-platform Data with Sample Heterogeneity.
Pathway-guided Identification of Gene-Gene Interaction.
Annals of Human Genetics, 78:478-491, PMCID: PMC4363308 [Paper]
Analysis of gene-gene interactions using gene-trait similarity regression.
Human Heredity, 78:17-26 PMCID: PMC4115296 [Paper]
Heritability and Genomics of Gene Expression in Peripheral Blood.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Nature Genetics. doi: 10.1038/ng.2711 [Paper]
Establishment of reference standards in biosimilar studies.
Generics and Biosimilars Initiative Journal. 2. NIHMSID: NIHMS554364 [Paper]
Statistical Considerations in Biosimilar Assessment Using Biosimilarity Index.
Journal of Bioequivalence and Bioavailability. 5: 209-214. NIHMSID: NIHMS555465 [Paper]
A mega-analysis of genome-wide association studies for major depressive disorder.
Multivariate Phenotype Association Analysis by Marker-Set Kernel Machine Regressions.
On the aggregation of multimarker information for marker-set and sequencing data analysis: genotype collapsing vs. similarity collapsing.
Frontiers in Statistical Genetics and Methodology. 2:110 [Paper]
Detecting gene and gene-environment effects of common and uncommon variants on quantitative traits: A marker-set approach using gene-trait similarity regression.
Combining an evolution-guided clustering algorithm and haplotype-based likelihood ratio test in family-based association studies.
Evaluating Haplotype Effects in Case-Control Studies via Penalized-Likelihood Approaches: Prospective or Retrospective Analysis?.
A Quality Control Algorithmm for Filtering SNPs in Genomewide Association Studies.
Haplotype-based Pharmacogenetic Analysis for Longitudinal Quantitative Traits in the Presence of Dropout.
Journal of Biopharmaceutical Statistics (Special Issue of Statistical Genomics in Clinical Trials). 20:334-50. [Paper] [R-Code]
A Comprehensive Approach to Haplotype Specific Analysis via Penalized Likelihood.
A Regression-Based Association Test Using Inferred Ancestral Haplotype Similarity.
Annals of Human Genetics. 73:520-526. [Paper]
Gene-Trait Similarity Regression for Multimarker-based Association Analysis.
Genomewide Association for Major Depressive Disorder: a Possible Role for the Presynaptic Protein Piccolo.
Molecular Psychiatry 14:359-375. [Paper]
Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders.
The American Journal of Psychiatry. 166:540-556. [Paper]
Retrospective Haplotype Clustering Methods for Detecting Haplotypes Effects and Haplotype-Environment Interactions.
Institute of Statistics MimeoSeries No. 2611 [Paper]
Genomewide association for schizophrenia in the CATIE study.
Molecular Psychiatry.13:570-84. [Paper]
Haplotype-based association analysis via variance component score test.
Regression-based association analysis with clustered haplotypes using genotypes.
Comment on "Likelihood-based inference on haplotype effects in genetic association studies".
Journal of the American Statistical Association, 101:111-114.
A two-stage design for multiple testing in large-scale association studies.
Journal of Human Genetics, 51:523-532. [Paper]
Evolutionary-based Grouping of Haplotypes in Association Analysis.
Genetic Epidemiology, 28:220-231. [Paper]
Outlier detection and false discoveryrates for whole-genome DNA matching.
Journal of the American Statistical Association, 98:236-246. [Paper]
On the identification of disease mutations by the analysis of haplotype similarity and goodness-of-fit.
Comparing the performance of two indexes for spatial model selection: applications to two mortality data.
Statistics in Medicine, 19:1915-1930. [Paper]
Design and statistical analysis for the myopia intervention trial in Taiwan.
In Lin, L.L.-K., Shih, Y.-F. and Hung, P.T. (Eds.), MyopiaUpdates II (pp. 161-164). Springer-Verlag, Tokyo.
Spatial model selection using Bayes factor and ratio of variabilities for asthma mortality data.
Chinese Journal of Public Health, 17:158-169.
Chinese version of "Primer of Biostatistics (4th ed.) by Glantz, S.A.".