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| Eric A. Stone |
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| Assistant Professor of Statistics |
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| Dr. Eric A. Stone began his career at North Carolina State University in 2005. He received his B.S. in 1996 from the University of Florida and his M.S. in 2001 from Stanford University. He received his Ph.D. in 2004 from Stanford University. |
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Choi SC, Stone EA, Kishino H, Thorne JL:
Estimates of natural selection due to protein tertiary structure inform the ancestry of biallelic loci.
Gene 2008 (doi: 10.1016/j.gene.2008.07.020) |
Stone EA, Sidow A:
Constructing a meaningful evolutionary average at the phylogenetic center of mass.
BMC Bioinformatics 2007, 8: 222 |
Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, et al:
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome.
Genome Research 2007, 17: 760-774 |
Hsieh W-P, Passador-Gurgel G, Stone EA, Gibson G:
Mixture modeling of transcript abundance classes in natural populations.
Genome Biology 2007, 8: R98 |
The ENCODE Project Consortium:
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
Nature 2007, 447: 799-816 |
Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, et al:
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B.
Cancer Research 2006, 66: 10179-87 |
Stone EA, Cooper GM, Sidow A:
Trade-offs in detecting evolutionary constrained sequence by comparative genomics.
Annual Review of Genomics and Human Genetics 2005, 6: 143-164 |
Stone EA, Sidow A:
Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity.
Genome Research 2005, 15: 978-986 |
Cooper GM, Stone EA, Asimenos G, Green ED, Batzoglou S, Sidow A:
Distribution and intensity of constraint in mammalian genomic sequence.
Genome Research 2005, 15: 901-913 |
| Kashuk CS†, Stone EA†, Grice EA, Portnoy ME, Green ED, et al: Phentotype-genotype correlation in Hirschsprung disease is illuminated by comparative analysis of the RET protein sequence. Proceedings of the National Academy of Sciences 2005, 102: 8949-8954 († Equal contributors) |
The ENCODE Consortium:
The ENCODE (ENCylopedia of DNA Elements) Project.
Science 2004, 306: 636-640 |
Rat Genome Sequencing Project Consortium:
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Nature 2004, 428: 493-521 |
Cooper GM, Brudno M, Stone EA, Dubchak I, Batzoglou S, Sidow A:
Characterization of evolutionary rates and constraints in three mammalian genomes.
Genome Research 2004,14: 539-548 |
Simon AL, Stone EA, Sidow A:
Inference of functional regions in proteins by quantification of evolutionary constraints.
Proceedings of the National Academy of Sciences 2002, 99: 2912-2917 |
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| Software: |
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| Program |
Description |
| MAPP (java) |
Predicts nsSNP phenotype from aligned protein orthologs |
| BM (R) |
Calculates principled taxon weights from an unrooted tree |
| MMC (Matlab) |
Implements modulated modularity clustering (coming soon) |
| RContrast |
-- coming soon -- |
| SpecNJ |
-- coming soon -- |
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North Carolina State University
Raleigh, North Carolina 27695
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