Expect frequent changes

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1

Jan 11

Class canceled

Read Chap.2

2

Jan 13

Overview of Bayeaisn approach
Examples: Binomial and Normal distributions

Read Sections 3.2,3.3,3.5,3.6 & 3.7
HW0: 2.1, 2.2, 2.4, 2.7, 2.10 (submission optional)

3

Jan 18

No class

Holiday (Martin Luther King, Jr. Day); university closed

4

Jan 20

Bayesian Inference:
Point and Region estimation and Hypothesis testing

Read Sections 3.8, 3.12 & 3.13

5

Jan 25

Numerical Integration methods
A survey of numerical integration using R

R codes: Univariate case
R codes: Bivariate case

6

Jan 27

Non-inferiority trials for dichotomous data
(by guest lecturer: Muhtar Osman)

Read paper Osman and Ghosh (2010)
HW1: 3.1, 3.2 & 3.7

7

Feb 1

Monte Carlo Integration methods
A primer on MCMC (by Jeff Gill)

R codes: Univariate case

8

Feb 3

Introduction to WinBUGS

Read WinBUGS demo Slides (by S.A. Bashir)
HW2: 3.3, 3.4 & 3.5

9

Feb 8

Interface between R and WinBUGS

R codes: R2WinBUGS-logit (performs simulation study)
WinBUGS code: logitmodel

10

Feb 10

Sample size determination

Adcock (1997), The Statistician, pp.261-283
Pezeshk (2003), Statistical Methods in Medical Research, pp.489-504

11

Feb 15

Bayesian sample size determination

Read Joseph and Belise (1997), The Statistician, pp.209-226
R packages: SampleSizeMeans and SampleSizeProportions

12

Feb 17

Comparing Bayesian and Frequestist Tests

R codes: Compare power curves
R codes: Sample size calculations

13

Feb 22

Overview of Clinical Trials

Read Chap 6
Also read Chap.1 ST 520 Lecture Notes (Courtsey Drs. Zhang and Tsiatis)

14

Feb 24

Overview of Phase I-III trials

Read Chaps. 2 & 3 ST 520 Lecture Notes (Courtsey Drs. Zhang and Tsiatis)

15

Mar 1

Bayesian two-stage designs
Midterm project

R codes: Two stage designs

16

Mar 3

Meta analysis

WinBUGS code: Comparing 5-FU treatments

17

Mar 8

Survival anlysis in Phase III trails

Read Chap. 9 ST 520 Lecture Notes (Courtsey Drs. Zhang and Tsiatis)

18

Mar 10

Bayesian survival analysis

Midterm project due TODAY!
WinBUGS code: Fitting censored data models

19

Mar 15

No Class

Spring Break

20

Mar 17

No Class

Spring Break

21

Mar 22

Phase I Studies

Read Selected slides ST 520 Lecture Notes (Courtsey Drs. Zhang and Davidian)

22

Mar 24

Bayesian Dose-response curve fitting

Read Bailer et al. (2005)
WinBUGS code: Dose response models

23

Mar 29

Nonparametric Bayes methods to estimate response curve

Curtis and Ghosh (2010)
Bornkamp and Ickstadt (2009) Biometrics 65(1), 198–206

24

Mar 31

Complex Meta analysis

WinBUGS codes

25

Apr 5

Meta analysis for rare events

WinBUGS codes

26

Apr 7

Introduction to Cost effectiveness studies

Project Abstract due TODAY!

27

Apr 12

Parameteric approches

WinBUGS codes

28

Apr 14

Nonparametric approaches

WinBUGS codes

29

Apr 19

ROC Analysis

Fawcett (2006)
Gu, Ghoshal and Roy (2008)
Gu and Ghosal (2009)

30

Apr 21

Estimating Area Under the Curve (AUC)

Peng and Hall (1996)
WinBUGS code:AUC.odc

31

Apr 26

Review of Bayesian Biostatistics

Hess (2007)

32

Apr 28

Project Presentations

Eric Reyes: 1:30-1:55, Title: Bayesian Average Error Based Approaches to Sample Size Calculations for Hypothesis Testing
Phillip Schulte: 1:55-2:20, Title: Bayesian Modeling of Rare Event Data
Seung Shin: 2:20-2:45, Title: Maximum tolerance dose estimation using nonparametric Bayesian curve estimator with Bernstein polynomials