Associate Professor

Assistant Department Head


Bioinformatics Consulting and Service Core

University Faculty Scholar

Bioinformatics Research Center

Department of Statistics

4223 Broughton Hall

2601 Stinson Dr.

Campus Box 7566

Raleigh NC 27695

Tel: (919) 515-3574

Fax: (919) 515-7315



Alison Motsinger-Reif, PhD

The primary goal of my research is the development of computational methods to detect genetic risk factors of common, complex traits in human populations.  As the field of human genetics increasingly accepts a complex model of phenotypic development that involving many genetic and environment factors, it is increasingly important to develop analytical strategies that incorporates this complexity.  Data collected from different physiological compartments that represent biological flux across time and space (such as genetic, proteomic, and environmental data) will need to be incorporated to gain a fuller understanding of the biological mechanism underlying complex phenotypes. My research is focused on the development of methods to detect such complex predictive models in high-throughput genomic data.

While methods development is a key component of my research, real data applications are the driving factor.  In particular, I work on performing association mapping to detect genes that are associated with differential response to pharmaceutical agent exposure.  I also collaborate with a number of investigators trying to understand complex human diseases, to compare disease etiology across species, to perform gene mapping in fruit flies, and many more!

I regularly teach both graduate and undergraduate courses, including the following courses:

Statistical Genetics Practicum (STAT 498, ST489)

Readings (STAT 635)

Bioinformatics Consulting (STAT 610/ STAT 810)

Introduction to Statistics (STAT 311)

Additionally, I am the Director of the Bioinformatics Consulting and Service Core.  For more information on the core, see below:

For more details on teaching and research, please see my CV:


or my Google Scholar profile:

Links to Collaborators and Programs I am actively involved in:

Bioinformatics Research Center

Computation for Undergrads in Statistics Program

Institute for Pharmacogenomics and Individualized Therapy

Pharmacogenomics for Every Nation Initiative

Summer Institute of Statistical Genetics

1st Short Course on Statistical Genetics and Genomics

Center for Comparative Medicine and Translational Research

Center for Human Health and the Environment

Last Updated February 26, 2014