Department of Statistics

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Research Interests:

Statistical Genetics---statistical methods for studying susceptibility genes for complex traits, association analysis, haplotype-similarity methods, haplotype-based analysis, outlier detection, EM algorithm, multiple testing/false discovery rate, Bayes hierarchical modeling

Publications:

• Tzeng, J.Y., Bondell, H. (2008). A Novel Approach to Haplotype Specific Analysis via Penalized Likelihood. Submitted.
• Sullivan P, de Geus E, Willeen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Dohke M, Farmer A, Fava M, Gordon SD, He Q, Heath A, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, MacIntyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery G, Muir WJ, Nolen W, Nothen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng J.Y, van Dyck R, Verhage M, G. ZF, Martin NG, Wray NR, Booma DI, Penninx B. (2008) Genomewide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry. In press.
• Lee, M.H., Tzeng J.Y., Huang, S.Y., Hsiao, C.K. (2008). Family-based Association Test Using Evolution-guided Clustering of Haplotypes. Submitted.
• Tzeng J.Y., Zhang D., Chang S.M., Thomas D.C., Davidian M. (2008). Gene-Trait Similarity Regression for Multimarker-baed Association Analysis. Biometrics. In press.
• Jones M.L., Epstein M.P., Kao J.T., Allen A.S., Satten G.A., Tzeng J.Y. (2008). Retrospective Haplotype Clustering Methods for Detecting Haplotypes Effects and Haplotype-Environment Interactions, Institute of Statistics Mimeo Series No.2611
• Sullivan P.F., Lin D., Tzeng J.Y., van den Oord E.J.C.G., Perkins D., Stroup T.S., Wagner M., Lee S., Wright F.A., Zou F., Liu W., Downing A.C., Lieberman J.A., Close S.L. Genomewide association for schizophrenia in the CATIE study. Molecular Psychiatry. 13:570-84.
• Tzeng, J.Y., Zhang, D. (2007). Haplotype-based association analysis via variance component score test. The American Journal of Human Genetics. 81:927-938.
• Liu, Y., Li, Y.J, Satten, G., Allen, A.S.,Tzeng, J.Y. (2007). A regression-based association test using inferred ancestral haplotype similarity. Submitted.
• Tzeng, J.Y., Wang, C.H., Kao, J.T., and Hsiao, C.K. (2006). Regression-based association analysis with clustered haplotypes using genotypes. The American Journal of Human Genetics, 78:231-242.
• Tzeng, J.Y. and Roeder, K. (2006). Comment on "Likelihood-based inference on haplotype effects in genetic association studies". Journal of the American Statistical  Association, 101:111-114.
• Wen, S.H , Tzeng, J.Y., Kao, J.T., and Hsiao, C.K. (2006). A two-stage design for multiple testing in large-scale association studies. Journal of Human Genetics, 51:523-532.
• Tzeng, J.Y. (2005).Evolutionary-based Grouping of Haplotypes in Association Analysis. Genetic Epidemiology, 28:220-231.
• Tzeng, J.Y., Byerley, W., Devlin, B., Roeder, K. and Wasserman, L. (2003). Outlier detection and false discovery rates for whole-genome DNA matching. Journal of the American Statistical Association, 98:236-246.
• Tzeng, J.Y., Devlin, B., Wasserman, L. and Roeder, K. (2003). On the identification of disease mutations by the analysis of haplotype similarity and goodness-of-fit. The American Journal of Human Genetics, 72:891-902.
• Hsiao, C.K., Tzeng, J.Y., and Wang, C.H. (2000).Comparing the performance of two indexes for spatial model selection: applications to two mortality data. Statistics in Medicine, 19:1915-1930.
• Hsiao, C.K., Chen, C.J., Shih, Y.-F., Lin, LL.-K., Hung, P.T., Yao, C.L., Su, T.C., Lin, T.C., Tzeng, J.Y., and Chen, Y. (2000). Design and statistical analysis for the myopia intervention trial in Taiwan. In Lin, L.L.-K., Shih, Y.-F. and Hung, P.T. (Eds.), Myopia Updates II (pp. 161-164). Springer-Verlag, Tokyo.
• Tzeng, J.Y., Hsiao, C.K. and Chen, C.J. (1998). Spatial model selection using Bayes factor and ratio of variabilities for asthma mortality data. Chinese Journal of Public Health, 17:158-169.
• Cheng, Y.H. and Tzeng, J.Y. (1997). Chinese version of "Primer of Biostatistics (4th ed.) by Glantz, S.A.'', McGraw-Hill, Taipei.

Research Grant:

• 08/15/2005 - 07/31/2009 Principal Investigator, Haplotype-based Association Modeling for Whole-Genome Scan and Candidate Gene Studies, DMS-0504726, NSF.

• 03/15/06 - 02/28/09 Co-Investigator, Replication of Schizophrenia Associations in CATIE: Subconstruct from UNC-CH, R01-MH074027 (PI: Patrick Sullivan) NIMH.

Software:

• Codes for Quadratic Statistics of Haplotype Similarity (QSHS) : (To facilitate updating, please send tzeng@stat.ncsu.edu a blank email with subject "QSHS codes" before download)

Manual
R Codes

• R code for Evolutionary-based haplotype clustering (Tzeng 2005; Tzeng et al. 2006): (To facilitate updating, please send tzeng@stat.ncsu.edu a blank email with subject "Hap clustering codes" before download)

• R code for Variance Component Score test (Tzeng and Zhang 2007)---a haplotype association test for genome-wide association analysis: (To facilitate updating, please send tzeng@stat.ncsu.edu a blank email with subject "Hap clustering codes" before download)

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