subject dose time resp ind = 1 if PK, 0 if PD

1 1 1 0 26.1 0
2 1 1 120 42.7 0
3 1 1 240 43 0
4 1 1 270 35.4 0
5 1 1 300 33.9 0
6 1 1 360 26.3 0
7 1 1 30 95.7 1
8 1 1 60 122 1
9 1 1 90 133 1
10 1 1 160 162 1
11 1 1 200 200 1
12 1 1 240 172 1
13 1 1 245 122 1
14 1 1 250 120 1
15 1 1 260 60.6 1
16 1 1 275 70 1
17 1 1 295 47.3 1
18 2 1 0 26.5 0
19 2 1 120 42.1 0
20 2 1 240 46.5 0
21 2 1 270 34.8 0
22 2 1 360 26.8 0
23 2 1 30 138 1
24 2 1 60 188 1
25 2 1 90 190 1
26 2 1 115 211 1
27 2 1 160 168 1
28 2 1 200 249 1
29 2 1 240 208 1
30 2 1 245 138 1
31 2 1 250 121 1
32 2 1 260 114 1
33 2 1 275 77.8 1
34 3 1 0 28.7 0
35 3 1 120 44.3 0
36 3 1 240 42.3 0
37 3 1 270 31.8 0
38 3 1 300 32.5 0
39 3 1 360 27.3 0
40 3 1 30 115 1
41 3 1 60 153 1
42 3 1 90 126 1
43 3 1 115 179 1
44 3 1 160 173 1
45 3 1 200 208 1
46 3 1 240 142 1
47 3 1 245 78.7 1
48 3 1 250 72 1
49 3 1 260 41.6 1
50 3 1 275 42 1
51 4 1 0 28 0
52 4 1 120 48.3 0
53 4 1 240 53.7 0
54 4 1 270 41.2 0
55 4 1 300 38.9 0
56 4 1 360 33.3 0
57 4 1 30 71.9 1
58 4 1 60 138 1
59 4 1 90 135 1
60 4 1 115 164 1
61 4 1 160 164 1
62 4 1 200 180 1
63 4 1 240 182 1
64 4 1 245 143 1
65 4 1 250 106 1
66 4 1 260 89.8 1
67 4 1 275 61.3 1
68 4 1 295 53.3 1
69 5 1.5 0 24.6 0
70 5 1.5 120 45.4 0
71 5 1.5 240 48.2 0
72 5 1.5 270 35.5 0
73 5 1.5 300 28.5 0
74 5 1.5 360 28.4 0
75 5 1.5 30 164 1
76 5 1.5 60 207 1
77 5 1.5 90 213 1
78 5 1.5 115 231 1
79 5 1.5 160 285 1
80 5 1.5 200 254 1
81 5 1.5 240 234 1
82 5 1.5 245 205 1
83 5 1.5 250 170 1
84 5 1.5 260 129 1
85 5 1.5 275 67.3 1
86 5 1.5 295 49.5 1
87 5 1.5 320 32.7 1
88 6 1.5 0 28.2 0
89 6 1.5 120 50.2 0
90 6 1.5 240 49.4 0
91 6 1.5 270 36.3 0
92 6 1.5 300 36.5 0
93 6 1.5 360 31.7 0
94 6 1.5 30 116 1
95 6 1.5 60 156 1
96 6 1.5 90 131 1
97 6 1.5 115 143 1
98 6 1.5 160 248 1
99 6 1.5 200 212 1
100 6 1.5 240 154 1
101 6 1.5 245 124 1
102 6 1.5 250 94.7 1
103 6 1.5 260 55.3 1
104 6 1.5 275 49.6 1
105 7 1.5 0 29.5 0
106 7 1.5 120 55.7 0
107 7 1.5 240 61.2 0
108 7 1.5 270 44.7 0
109 7 1.5 300 42.3 0
110 7 1.5 360 34.9 0
111 7 1.5 30 330 1
112 7 1.5 60 353 1
113 7 1.5 90 348 1
114 7 1.5 115 346 1
115 7 1.5 160 696 1
116 7 1.5 200 628 1
117 7 1.5 240 565 1
118 7 1.5 245 423 1
119 7 1.5 250 269 1
120 7 1.5 260 305 1
121 7 1.5 275 207 1
122 7 1.5 295 159 1
123 7 1.5 320 113 1
124 7 1.5 360 43 1
125 8 1.5 0 25 0
126 8 1.5 120 45.2 0
127 8 1.5 240 40 0
128 8 1.5 270 31.3 0
129 8 1.5 300 29.3 0
130 8 1.5 360 27 0
131 8 1.5 30 174 1
132 8 1.5 60 190 1
133 8 1.5 90 195 1
134 8 1.5 115 188 1
135 8 1.5 160 126 1
136 8 1.5 200 92.3 1
137 8 1.5 240 191 1
138 8 1.5 245 148 1
139 8 1.5 250 116 1
140 8 1.5 260 86.6 1
141 8 1.5 275 63.7 1
142 8 1.5 295 44.5 1
143 9 2 0 22.9 0
144 9 2 120 33.9 0
145 9 2 240 38.9 0
146 9 2 270 27.3 0
147 9 2 300 27.4 0
148 9 2 30 328.8 1
149 9 2 60 401.2 1
150 9 2 90 420.3 1
151 9 2 115 421.1 1
152 9 2 160 392.8 1
153 9 2 200 439.6 1
154 9 2 240 375 1
155 9 2 245 253.5 1
156 9 2 250 176.4 1
157 9 2 260 128.6 1
158 9 2 275 863.2 1
159 9 2 295 69.6 1
160 10 2 0 27.3 0
161 10 2 120 47.7 0
162 10 2 240 49.8 0
163 10 2 270 38.4 0
164 10 2 300 31.7 0
165 10 2 360 26.4 0
166 10 2 30 281.4 1
167 10 2 60 359.7 1
168 10 2 90 360.8 1
169 10 2 115 390.6 1
170 10 2 160 461.1 1
171 10 2 200 495.1 1
172 10 2 240 443 1
173 10 2 245 355 1
174 10 2 250 314.2 1
175 10 2 260 248 1
176 10 2 275 158.2 1
177 10 2 295 97.6 1
178 10 2 320 49.1 1
179 11 2 0 22 0
180 11 2 120 43.3 0
181 11 2 240 44.3 0
182 11 2 270 36.2 0
183 11 2 360 29.4 0
184 11 2 30 388.6 1
185 11 2 60 491.4 1
186 11 2 90 530 1
187 11 2 115 589.3 1
188 11 2 160 667.7 1
189 11 2 200 709.9 1
190 11 2 240 577.6 1
191 11 2 260 429 1
192 11 2 275 425.5 1
193 11 2 295 261.1 1
194 11 2 320 211 1
195 11 2 360 161.7 1
196 12 2 0 28 0
197 12 2 120 47 0
198 12 2 240 44.5 0
199 12 2 270 33.7 0
200 12 2 300 30.9 0
201 12 2 360 28.2 0
202 12 2 30 327.7 1
203 12 2 60 454.7 1
204 12 2 90 438.4 1
205 12 2 115 488.7 1
206 12 2 160 469.8 1
207 12 2 200 487.4 1
208 12 2 240 450.1 1
209 12 2 245 329.7 1
210 12 2 250 279.1 1
211 12 2 260 211 1
212 12 2 275 140.2 1
213 12 2 295 77.2 1
214 12 2 320 68.7 1
215 12 2 360 40.7 1
216 13 2.5 0 34.7 0
217 13 2.5 120 73.5 0
218 13 2.5 240 75.3 0
219 13 2.5 270 58.1 0
220 13 2.5 300 52.3 0
221 13 2.5 360 49.9 0
222 13 2.5 420 45.5 0
223 13 2.5 480 40.2 0
224 13 2.5 30 513.3 1
225 13 2.5 60 669.9 1
226 13 2.5 90 820.7 1
227 13 2.5 115 898 1
228 13 2.5 160 982.2 1
229 13 2.5 200 1002.6 1
230 13 2.5 240 1000.2 1
231 13 2.5 245 728.5 1
232 13 2.5 250 744.3 1
233 13 2.5 260 631.1 1
234 13 2.5 275 546 1
235 13 2.5 295 408.8 1
236 13 2.5 320 291 1
237 13 2.5 360 186.7 1
238 14 2.5 0 26.4 0
239 14 2.5 120 48.8 0
240 14 2.5 240 47.7 0
241 14 2.5 270 38.2 0
242 14 2.5 300 35.2 0
243 14 2.5 360 28.4 0
244 14 2.5 30 296.4 1
245 14 2.5 60 487 1
246 14 2.5 90 505.7 1
247 14 2.5 115 518.3 1
248 14 2.5 160 584.2 1
249 14 2.5 200 554.3 1
250 14 2.5 240 526.4 1
251 14 2.5 245 481 1
252 14 2.5 250 297.4 1
253 14 2.5 260 262.3 1
254 14 2.5 275 165.8 1
255 14 2.5 295 107.9 1
256 14 2.5 320 57.3 1
257 14 2.5 360 45.9 1
258 15 2.5 0 27.7 0
259 15 2.5 120 72.9 0
260 15 2.5 240 70.2 0
261 15 2.5 270 60.7 0
262 15 2.5 300 56.3 0
263 15 2.5 360 48.6 0
264 15 2.5 420 39.3 0
265 15 2.5 30 659.2 1
266 15 2.5 90 1054.8 1
267 15 2.5 115 965.9 1
268 15 2.5 160 1111.1 1
269 15 2.5 200 1203.6 1
270 15 2.5 240 1268.8 1
271 15 2.5 245 1016 1
272 15 2.5 250 932.1 1
273 15 2.5 260 884.3 1
274 15 2.5 275 705.5 1
275 15 2.5 295 323.5 1
276 15 2.5 320 462.7 1
277 15 2.5 360 441.3 1
278 16 2.5 0 29.4 0
279 16 2.5 120 49.8 0
280 16 2.5 240 51.2 0
281 16 2.5 270 44.9 0
282 16 2.5 300 35.2 0
283 16 2.5 360 34.2 0
284 16 2.5 30 412.7 1
285 16 2.5 60 493.5 1
286 16 2.5 90 623.3 1
287 16 2.5 115 652.2 1
288 16 2.5 200 480.6 1
289 16 2.5 240 658.5 1
290 16 2.5 245 518.6 1
291 16 2.5 250 412 1
292 16 2.5 260 243.8 1
293 16 2.5 275 235.9 1
294 16 2.5 295 151.1 1
295 16 2.5 320 101.7 1
296 17 3 0 21.2 0
297 17 3 120 51.9 0
298 17 3 240 58.6 0
299 17 3 270 41.5 0
300 17 3 300 38.7 0
301 17 3 360 32.1 0
302 17 3 30 579.5 1
303 17 3 60 849.1 1
304 17 3 90 928.8 1
305 17 3 115 1305.2 1
306 17 3 160 1272 1
307 17 3 200 1301.7 1
308 17 3 240 1288.4 1
309 17 3 245 1064 1
310 17 3 250 1041.2 1
311 17 3 260 1197.9 1
312 17 3 275 667.5 1
313 17 3 295 534.9 1
314 17 3 320 562.9 1
315 17 3 360 303.3 1
316 18 3 0 35.5 0
317 18 3 120 67 0
318 18 3 240 70.8 0
319 18 3 270 50.8 0
320 18 3 300 45.3 0
321 18 3 360 39.2 0
322 18 3 30 415.9 1
323 18 3 60 508.4 1
324 18 3 90 527.7 1
325 18 3 115 660.2 1
326 18 3 160 651.4 1
327 18 3 200 597.2 1
328 18 3 240 594.9 1
329 18 3 245 489.2 1
330 18 3 250 365.6 1
331 18 3 260 309.8 1
332 18 3 275 169.4 1
333 18 3 295 111.3 1
334 18 3 320 58.2 1
335 19 3 0 30.2 0
336 19 3 120 61.6 0
337 19 3 240 53.4 0
338 19 3 270 41 0
339 19 3 300 36.4 0
340 19 3 360 29.3 0
341 19 3 30 295.1 1
342 19 3 60 452.6 1
343 19 3 90 559.1 1
344 19 3 115 540.1 1
345 19 3 160 573.2 1
346 19 3 200 581.7 1
347 19 3 240 580.3 1
348 19 3 245 442.4 1
349 19 3 250 330 1
350 19 3 260 252 1
351 19 3 275 139 1
352 19 3 295 71.3 1
353 20 3 0 30.5 0
354 20 3 120 58.2 0
355 20 3 240 53.4 0
356 20 3 270 49.4 0
357 20 3 300 40.5 0
358 20 3 360 39.5 0
359 20 3 30 583.2 1
360 20 3 60 689.5 1
361 20 3 90 807 1
362 20 3 115 855.6 1
363 20 3 160 662.5 1
364 20 3 200 778.9 1
365 20 3 240 746.2 1
366 20 3 245 439.4 1
367 20 3 250 436.8 1
368 20 3 260 347.2 1
369 20 3 275 273 1
370 20 3 295 121.3 1
371 21 3.5 0 29.6 0
372 21 3.5 120 64.7 0
373 21 3.5 240 59.9 0
374 21 3.5 270 43 0
375 21 3.5 300 41.7 0
376 21 3.5 360 34.4 0
377 21 3.5 30 612.1 1
378 21 3.5 60 724.9 1
379 21 3.5 90 697.7 1
380 21 3.5 115 759.7 1
381 21 3.5 160 749.4 1
382 21 3.5 200 881.9 1
383 21 3.5 240 684.5 1
384 21 3.5 245 448.3 1
385 21 3.5 250 422.7 1
386 21 3.5 260 404.8 1
387 21 3.5 275 223 1
388 21 3.5 295 126 1
389 21 3.5 320 78.1 1
390 22 3.5 0 26.3 0
391 22 3.5 120 59.5 0
392 22 3.5 240 62.1 0
393 22 3.5 270 39.3 0
394 22 3.5 300 36.9 0
395 22 3.5 30 623 1
396 22 3.5 60 744.2 1
397 22 3.5 90 848.6 1
398 22 3.5 115 911.8 1
399 22 3.5 160 880.4 1
400 22 3.5 200 841.4 1
401 22 3.5 240 694.4 1
402 22 3.5 245 548.4 1
403 22 3.5 250 397.6 1
404 22 3.5 260 293.5 1
405 22 3.5 275 241.4 1
406 22 3.5 295 130.9 1
407 22 3.5 360 119.5 1
408 23 3.5 0 28 0
409 23 3.5 120 64.1 0
410 23 3.5 240 72.2 0
411 23 3.5 270 50.6 0
412 23 3.5 300 43.5 0
413 23 3.5 360 37 0
414 23 3.5 30 631.6 1
415 23 3.5 60 766.9 1
416 23 3.5 90 888.3 1
417 23 3.5 115 805 1
418 23 3.5 160 879.9 1
419 23 3.5 200 858.5 1
420 23 3.5 240 827.5 1
421 23 3.5 245 722.4 1
422 23 3.5 250 559.9 1
423 23 3.5 260 477.7 1
424 23 3.5 275 306.5 1
425 23 3.5 295 199 1
426 23 3.5 320 130.2 1
427 23 3.5 360 79.9 1
428 24 3.5 0 25.9 0
429 24 3.5 120 60.5 0
430 24 3.5 240 70.3 0
431 24 3.5 270 49.9 0
432 24 3.5 300 40 0
433 24 3.5 360 36.5 0
434 24 3.5 30 570.7 1
435 24 3.5 60 711.7 1
436 24 3.5 90 724.9 1
437 24 3.5 115 905.3 1
438 24 3.5 160 849.8 1
439 24 3.5 200 802.6 1
440 24 3.5 240 890.4 1
441 24 3.5 245 711 1
442 24 3.5 250 672.8 1
443 24 3.5 260 498.1 1
444 24 3.5 275 368.2 1
445 24 3.5 295 166.4 1
446 24 3.5 320 112.4 1
447 24 3.5 360 68.2 1
448 25 4 0 27.8 0
449 25 4 120 56.2 0
450 25 4 240 73.6 0
451 25 4 360 38.5 0
452 25 4 420 36.7 0
453 25 4 30 779 1
454 25 4 60 962 1
455 25 4 90 1274 1
456 25 4 115 1427 1
457 25 4 160 1196 1
458 25 4 200 1476 1
459 25 4 240 989 1
460 25 4 245 855 1
461 25 4 250 958 1
462 25 4 260 518 1
463 25 4 275 595 1
464 25 4 295 427 1
465 25 4 320 246 1
466 25 4 360 101 1
467 26 4 0 27.7 0
468 26 4 120 62 0
469 26 4 240 57.4 0
470 26 4 270 38.5 0
471 26 4 300 32.7 0
472 26 4 360 29.5 0
473 26 4 30 354 1
474 26 4 60 504 1
475 26 4 90 747 1
476 26 4 115 690 1
477 26 4 160 817 1
478 26 4 200 728 1
479 26 4 240 764 1
480 26 4 245 388 1
481 26 4 250 288 1
482 26 4 260 172 1
483 26 4 275 79 1
484 26 4 295 79 1
485 26 4 320 52 1
486 27 4 0 29.9 0
487 27 4 120 73.9 0
488 27 4 240 72.7 0
489 27 4 270 64 0
490 27 4 300 58.6 0
491 27 4 360 46.1 0
492 27 4 420 39.5 0
493 27 4 30 734 1
494 27 4 60 1206 1
495 27 4 90 1002 1
496 27 4 115 1617 1
497 27 4 160 1594 1
498 27 4 200 1701 1
499 27 4 240 1422 1
500 27 4 245 1182 1
501 27 4 250 1321 1
502 27 4 260 1208 1
503 27 4 275 913 1
504 27 4 295 438 1
505 27 4 320 463 1
506 27 4 360 356 1
507 28 4 0 29.1 0
508 28 4 120 62.1 0
509 28 4 240 60.7 0
510 28 4 300 49.9 0
511 28 4 360 42.2 0
512 28 4 30 743 1
513 28 4 60 781 1
514 28 4 90 1129 1
515 28 4 115 1354 1
516 28 4 160 1149 1
517 28 4 200 1401 1
518 28 4 240 1428 1
519 28 4 250 1431 1
520 28 4 295 394 1
521 28 4 360 191 1
522 29 4.5 0 24.5 0
523 29 4.5 120 56.4 0
524 29 4.5 240 54.7 0
525 29 4.5 360 37.2 0
526 29 4.5 30 599 1
527 29 4.5 60 726 1
528 29 4.5 90 838 1
529 29 4.5 115 885 1
530 29 4.5 160 844 1
531 29 4.5 200 854 1
532 29 4.5 240 829 1
533 29 4.5 245 659 1
534 29 4.5 250 545 1
535 29 4.5 260 401 1
536 29 4.5 275 276 1
537 29 4.5 295 184 1
538 29 4.5 320 139 1
539 29 4.5 360 55 1
540 30 4.5 0 27.2 0
541 30 4.5 120 62 0
542 30 4.5 240 60.2 0
543 30 4.5 270 43.7 0
544 30 4.5 300 37 0
545 30 4.5 360 32.7 0
546 30 4.5 30 529 1
547 30 4.5 60 635 1
548 30 4.5 90 771 1
549 30 4.5 115 768 1
550 30 4.5 160 867 1
551 30 4.5 200 864 1
552 30 4.5 240 806 1
553 30 4.5 245 566 1
554 30 4.5 250 465 1
555 30 4.5 260 314 1
556 30 4.5 275 212 1
557 30 4.5 295 165 1
558 30 4.5 320 63 1
559 31 4.5 0 25.2 0
560 31 4.5 120 54.2 0
561 31 4.5 240 57.5 0
562 31 4.5 270 38.7 0
563 31 4.5 300 35.3 0
564 31 4.5 360 31.4 0
565 31 4.5 30 575 1
566 31 4.5 60 637 1
567 31 4.5 90 584 1
568 31 4.5 115 608 1
569 31 4.5 160 619 1
570 31 4.5 200 690 1
571 31 4.5 240 618 1
572 31 4.5 245 415 1
573 31 4.5 250 370 1
574 31 4.5 260 271 1
575 31 4.5 275 209 1
576 31 4.5 295 110 1
577 31 4.5 320 76 1
578 32 4.5 0 25.7 0
579 32 4.5 120 63 0
580 32 4.5 240 64.2 0
581 32 4.5 270 44.3 0
582 32 4.5 300 31.4 0
583 32 4.5 360 32.9 0
584 32 4.5 30 637 1
585 32 4.5 60 837 1
586 32 4.5 90 996 1
587 32 4.5 115 1047 1
588 32 4.5 160 1018 1
589 32 4.5 200 985 1
590 32 4.5 240 1119 1
591 32 4.5 245 937 1
592 32 4.5 250 766 1
593 32 4.5 260 569 1
594 32 4.5 275 467 1
595 32 4.5 295 220 1
596 32 4.5 320 175 1
597 32 4.5 360 110 1
598 33 5 0 28.2 0
599 33 5 120 95.8 0
600 33 5 240 99.3 0
601 33 5 270 80.3 0
602 33 5 300 82.3 0
603 33 5 360 64.5 0
604 33 5 420 55.3 0
605 33 5 480 49.5 0
606 33 5 540 38.5 0
607 33 5 30 904 1
608 33 5 60 1568 1
609 33 5 90 1721 1
610 33 5 115 1839 1
611 33 5 160 2137 1
612 33 5 200 2191 1
613 33 5 240 2405 1
614 33 5 245 1937 1
615 33 5 250 2013 1
616 33 5 260 1671 1
617 33 5 275 1362 1
618 33 5 295 1062 1
619 33 5 320 891 1
620 33 5 360 584 1
621 34 5 0 24.3 0
622 34 5 120 61 0
623 34 5 240 53.4 0
624 34 5 270 40.7 0
625 34 5 300 36.3 0
626 34 5 360 29.9 0
627 34 5 30 655 1
628 34 5 60 958 1
629 34 5 90 1088 1
630 34 5 115 1040 1
631 34 5 160 1158 1
632 34 5 200 1108 1
633 34 5 240 1073 1
634 34 5 245 772 1
635 34 5 250 637 1
636 34 5 260 520 1
637 34 5 275 339 1
638 34 5 295 232 1
639 34 5 320 158 1
640 34 5 360 109 1
641 35 5 0 24.5 0
642 35 5 120 65.7 0
643 35 5 240 55.1 0
644 35 5 360 34.8 0
645 35 5 30 797 1
646 35 5 60 903 1
647 35 5 90 1034 1
648 35 5 115 1090 1
649 35 5 160 1192 1
650 35 5 200 1142 1
651 35 5 240 1196 1
652 35 5 245 966 1
653 35 5 250 823 1
654 35 5 260 695 1
655 35 5 275 511 1
656 35 5 295 341 1
657 35 5 320 279 1
658 35 5 360 132 1
659 36 4.38 0 29 0
660 36 4.38 120 52.9 0
661 36 4.38 240 57.5 0
662 36 4.38 270 36 0
663 36 4.38 300 34 0
664 36 4.38 360 32 0
665 36 4.38 30 403 1
666 36 4.38 60 456 1
667 36 4.38 90 518 1
668 36 4.38 115 569 1
669 36 4.38 160 656 1
670 36 4.38 200 627 1
671 36 4.38 240 665 1
672 36 4.38 245 366 1
673 36 4.38 250 338 1
674 36 4.38 260 266 1
675 36 4.38 275 176 1
676 36 4.38 295 97 1
677 36 4.38 320 56 1
678 37 5 0 27.7 0
679 37 5 120 58.7 0
680 37 5 240 52.2 0
681 37 5 270 40.2 0
682 37 5 300 40 0
683 37 5 360 33.7 0
684 37 5 30 587 1
685 37 5 60 653 1
686 37 5 90 736 1
687 37 5 115 764 1
688 37 5 160 748 1
689 37 5 200 790 1
690 37 5 245 330 1
691 37 5 250 320 1
692 37 5 260 223 1
693 37 5 275 137 1
694 37 5 295 78 1